Nick and Andrew are based off of the show's co-creators Nick Kroll and Andrew Goldberg, and much of the show's content reflects real events from their life. The other cast members also often served as inspiration for their respective characters. For example, Jenny Slate used to be quite small and wore overalls, like her character Missy, until one senior student came up to her and yelled to her: "Why do you look like a baby?"

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