The plot incorporates several storylines from "Iron Man" comics: The "Extremis" arc, which involved Tony Stark developing and using the Extremis virus, a nanotech version of Captain America's serum. Tony Stark is ousted, and rendered a homeless vagrant, and while wandering around, befriends a civilian who inspires him. The Mandarin seeks to use Extremis as a weapon of mass destruction. The "Invincible Iron Man" arc, where Stark goes on the run, and War Machine and Rescue appear in his place. The "Armor Wars" arc, where Tony Stark fakes his death, due to constant harassment by Firepower. The "Enter the Mandarin" arc, where Iron Man clashes with the Mandarin.

Film

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