Though Cruella's natural-born black and white hair might come off as completely fictional, it does have some basis in reality. Poliosis is a real-life hereditary condition that consists of a lack of pigmentation in a patch of hair on the scalp, resulting in it being completely white. It commonly occurs among people with Waardenburg syndrome. It is usually just a few streaks or patch. But there are cases of it being a spit on the middle effecting the hair on one side of the body

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