The film has engendered some confusion as to whether or not the virus is a worldwide phenomenon or whether it's confined to Britain. This is clarified on the DVD commentary, however. When shooting began, Danny Boyle and Alex Garland intended to reveal that the virus had spread worldwide, which is why Selena mentions outbreaks in Paris and New York early in the movie. However, as filming progressed, they changed their minds and decided to render the spread of the virus more ambiguous. As such, they wrote the dialogue spoken by Sergeant Farrell (Stuart McQuarrie) when he is tied to the radiator as a counter-theory to Selena's claims; he hypothesizes that Britain would have simply been quarantined at the first sign of trouble and that there was no way the virus could have reached America or mainland Europe. Obviously, the sequel 28 settimane dopo (2007) confirms that Farrell was entirely correct.

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