Writer and director John Lasseter hatched the idea for this movie while taking a cross-country trip on Route 66 with his wife and five sons in 2000, mainly at the behest of his wife Nancy Lasseter, who felt he was spending too much time at the studios. Nancy told her husband that he needed to make this film for all the people, largely women, who don't care about cars. Hence, the film's nickname during production was The Nancy Factor. Upon returning to work, he contacted Michael Wallis, a famous historian on the subject. Wallis then took eleven Pixar animators in rented white Cadilllacs on two different road trips across the route to research the film. The animators picked up artifacts en route; such items as wheat, thistles, snake skin, and road kill. All of these items were attached to the cars as hood ornaments, and then ceremoniously buried in the desert at the end of the trip.

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