The earliest example of Peter losing his powers was in the 'Unmasked by Doctor Octopus!' story that Sam Raimi cited as an influence on the film. In that issue, Peter was suffering from an illness that sapped him of his strength and made it harder for him to cling to walls. The untimely onset of these symptoms coincided with the return of Doc Ock, just as his loss of power does in the movie.

Film

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