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Four James Bond movies have featured leading Bond Girls with a doctor qualification. 'Spectre' (2015) was the third Bond movie where a major Bond Girl had been a doctor and it was the first James Bond movie in 16 years where a leading Bond Girl had the profession of being a doctor. In 'Spectre' (2015), Léa Seydoux's character is Dr. Madeleine Swann, a Doctor of Psychology, and she was the fourth major Bond Girl in the official franchise to be a doctor. Seydoux reprises this role in 'No Time to Die' (2021) making it the fourth Bond movie to have a leading Bond Girl being a doctor. The previous time in the film franchise prior to 'Spectre' (2015), that a Bond Girl was a doctor, there were two, Dr. Christmas Jones (Denise Richards), a doctor of nuclear physics, and Dr. Molly Warmflash (Serena Scott Thomas), a doctor, who is a physician to MI6 agents, and both appeared in Il mondo non basta (1999). Prior to this, the first leading Bond Girl who was a doctor, was Dr. Holly Goodhead (Lois Chiles), a CIA agent and an astronaut space scientist doctor of astrophysics in Moonraker - Operazione spazio (1979). In the James Bond video games, 007: Agent Under Fire (2001) featured Dr. Natalya Damescu (Beatie Edney, voice); James Bond 007: Everything or Nothing (2003) featured Dr. Katya Nadanova (Heidi Klum); and 007 Legends (2012) also features the above-mentioned Dr. Holly Goodhead (Jane Perry), while The World Is Not Enough (2000) also featured Dr. Christmas Jones (Sumalee Montano) as well as archive footage of Denise Richards from the movie version also in the video game. Also, this movie features a villain henchwoman called Dr. Vogel (Brigitte Millar), while the first James Bond theatrical arch-villain was called Agente 007 - Licenza di uccidere (1962). In Ian Fleming's James Bond novel "You Only Live Twice" (1964), the alias name of Ernst Stavro Blofeld is "Dr. Guntram Shatterhand".

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