When the historical Cleopatra VII, the last of the Ptolemaic dynasty, killed herself with a cobra bite, Egypt became a province of Rome. [Note: the method Cleopatra used for her suicide is not positively known - snake bite by asp or Egyptian cobra are most often cited; application of a toxic ointment or drinking a lethal herbal potion also have been postulated. Further, in 2010, a German historian suggested, based on a review of ancient documents and consultation with a toxicologist, she may have ingested a fatal mix of hemlock, wolfsbane, and opium.]

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