Sam Raimi hired Chuck Pfarrer as a writer based on his work on Navy Seals - Pagati per morire (1990). He wrote the first draft and then Raimi's brother, Ivan Raimi (a doctor), wrote drafts two through four with Sam. Ivan made sure that the medical aspects and scientific elements were authentic as possible given the nature of the story. As Raimi and his producing partner Rob Tapert progressed through various drafts, they realized that there potentially could be a sequel made, at some point. Universal brought in screenwriting brothers Daniel Goldin and Joshua Goldin to work on the script. According to Daniel, they were presented with various drafts and "lots of little story documents. There was just material everywhere; drafts seemed to go in many directions." Goldin said that they "spent a lot of time talking and pulling together a way of making the story work. I think that mostly we talked in terms of the nuts and bolts of the story." The Goldins added new lines of dialogue, new characters and bits of action. The studio still wasn't satisfied so the Raimi brothers wrote drafts six through twelve before they had a shooting script.

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