Dr. Jacoby is based on the late ethnobotanist Terence McKenna. Their physical appearance is strikingly similar, their dress style is similar and they are both in the liberal arts professions. Dr. Jacoby holidays in Hawaii and has a Hawaiian wife, while McKenna lived in Hawaii. Dr. Jacoby has a notable mushroom-shaped lamp, and McKenna studied and wrote widely on psychedelic mushroom culture. The tie-in book written by Mark Frost for the third season makes the link even more explicit with an excerpt from a book "written" by Jacoby on the therapeutic uses of psychotropic drugs.

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