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Despite Archimedes being considered the first forensic investigator in history, the actual forensic science as it's known (and as it is shown along the series) exists after fictional Sherlock Holmes, created by Arthur Conan Doyle for his 1887 novel A Study in Scarlet. However, the real-life investigator and the main source for Holmes is Dr. Joseph Bell, who was Doyle's teacher and mentor when he was student in the university, being the basis for the character. As Holmes, Bell was an accomplished forensic with special attributions for investigation and deduction, using the observation and giving relevance to any detail associated to determine if a corpse was victim of a crime and who could to commit it. The incredible popularity of Sherlock Holmes (Bell in spirit) and his impact in the popular culture around the world contributed to a large development of all the forensic sciences along of the 20th century. The character of Gil Grissom (William Petersen), and later his replacement D.B. Russell (Ted Danson), both have more than passing similarity to Sherlock Holmes. Like Holmes, Grissom is dispassionate with a fierce devotion to logic and little regard for societal norms of behavior; Grissom once smashed mustard jars in a grocery store to illustrate a theory, much as Holmes once practiced spearing a pig in a butchers to determine how strong a man would have to be to transfix a man with a harpoon. Grissom also possesses a Moriarty-like nemesis, Paul Millander (Matt O'Toole), whom he pursues in several episodes. Coincidentally, "Paul Millander" has the same initials as "Professor Moriarty." There's also a woman, Lady Heather Kessler (Melinda Clarke), in whom he takes an unusual interest. Their relationship is similar to that of Irene Adler and Holmes. Both Irene and Lady Heather enchant Holmes and Grissom with their beauty, their wit and their resolution. Lady Heather often wears Victorian-style dresses, referencing Holmes's era. Whilst D.B Russell's official character sheet was described as "A west coast Sherlock Holmes who devours crime novels and looks at every crime scene as if it were a story waiting to be told". Both Grissom and Russell work with their CSI partners Catherine Willows (Marg Helgenberger) and Julie Finlay (Elisabeth Shue), respectively (both the equivalent of John Watson) whilst both working under the Las Vegas Police Department's Homicide Captain Jim Brass (Paul Guilfoyle) (the equivalent of Inspector Lestrade). Other fictional 21st Century Detectives inspired by Sherlock Holmes are: Detective Robert Goren from Criminal Intent (2001).Adrian Monk from Detective Monk (2002).Shawn Spencer from Psych (2006).Patrick Jane from The Mentalist (2008).Also, even though he doesn't use his detective skills to solve crimes, Medical Doctor Gregory House from Dr. House - Medical Division (2004), uses Sherlock Holme's investigative technique to diagnose medical diseases.

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