On March 20, 2012, former The Riches star Eddie Izzard was announced by NBC as "Grandpa", the first of the prospective series' main roles to be cast. British actress Charity Wakefield joined the cast, playing Marilyn Munster, Lily's niece, and Spy Kids: All the Time in the World actor Mason Cook joined as Eddie Munster. On June 4, 2012, it was announced that Jerry O'Connell had been cast as family patriarch Herman Munster who series writer-producer Bryan Fuller describes as "essentially a zombie in a constant state of decay." On June 5, it was announced that Mariana Klaveno had been cast to play his wife Lily, contingent on her being released from her contract on Devious Maids. However, on June 12, 2012, it was announced that Portia de Rossi would play the role.

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